A method to identify which patients will have VT substrate ablation targets prior to ablation procedure

Abstract Funding Acknowledgements Type of funding sources: Foundation. Main source(s): Dr Nanthakumar is a recipient the Mid-career Investigator Award from Heart & Stroke Foundation Ontario Background Recent trials in ventricular tachycardia (VT) ablation suggest that early could reduce VT burden. A method to predict which patients will have substrate targets based on non-invasive testing prior procedure does not exist and be value selecting ideal for ablation. Decrement-evoked potential (DeEP) mapping used identify targets.1 predicting would DeEP pre-ablation 12-lead ECG has yet been developed. Objective To develop metric presence physiological ECG. Method 22 electrophysiology (EP) lab cases had undergone were extracted CARTO® 3 system analysed retrospectively. For each case, was calculated by subtracting last component nearfield evoked response pacing train (S1) latest decremented extra stimulus (S2). By inference, prediction width surface envelope S1 S2. Cases divided into three categories: - displaying intracardiac between 0-10ms – no 10-50ms positive >50ms prominent present Results Out cases, 8 characterised as targets, 12 positive, 2 present. The measurement means 3.5±4.6ms target group, 23.2±9.1ms 80.9±8.1ms group. decrement significantly different P<0.0001 groups. Consequently, we propose QRS widening 20ms or more may indicate during invasive mapping. Conclusion It possible detect ECG, procedure. Additionally, this rule, its association with arrhythmogenic potentials, able ambulatory who manifest VT, prone thus help candidates. This concept should validated larger data sets training using envelopes artificial intelligence algorithms.